Publications
2024
Recent Publications
Nuclear Lamins
- Kim PH, Kim JR, Heizer PJ, Jung H, Tu Y, Presnell A, Scheithauer J, Yu RG, Young SG, Fong LG. (2025) The accumulation of progerin underlies the loss of aortic smooth muscle cells in Hutchinson-Gilford progeria syndrome. Cell Death and Disease 16(1):557. doi: 10.1038/s41419-025-07853-0. PMID: 40707465. PMC12290114
Kim PA, Kim JR, Tu T, Jung H, Jeong JYB, Tran AP, Presnell A, Young SG, and Fong LG. (2024) Progerin forms an abnormal meshwork and has a dominant-negative effect on the nuclear lamina. Proc Natl Acad Sci USA. 121(27):e2406946121. doi: 10.1073/pnas.2406946121. PMID: 38917015. PMC11228511.
Triglyceride Metabolism
- Liu M, Hung M, Kozlov E, Hung M, Colaço-Gaspar M, Roy S, Tu Y, Magaki SD, Williams CK, Mäe MA, Johnson ECB, Siegel RW, Konrad RJ, Ploug M, Betsholtz C, Beigneux AP, He L, Fong LG, Young SG. (2026) GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain. Proc. Natl. Acad. Sci USA Jun 9;123(23):e2610646123. PMC132051
- Yang Y, Beigneux AP, Lowe TL, Chen YQ, Xie K, Jung H, Tu Y, Yu RG, Scheithauer JL, Mehta S, Wu J, Alvarez L, Davison WS, Birrane G, Remaley AT, Sviridov D, Ploug M, Zhen EY, Qian Y, Sloan JH, Siegel RW, Konrad RJ, Fong LG, Young SG. (2026) A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia. Proc. Natl. Acad. Sci USA 23(1):e2528664123. doi: 10.1073/pnas.2528664123. PMID: 41481469. PMC12773762
- Wenxin Song, Madison Hung, Ellen Kozlov, Megan Hung, Anh P. Tran, James Carroll, Le Phoung Nguyen, Troy L. Lowe, Paul Kim, Hyesoo Jung, Yiping Tu, Joonyoung Kim, Ashley M. Presnell, Julia Scheithauer, Jenna P. Koerner, Ye Yang, Shino D. Magaki, Christopher K. Williams, Michael Ploug, Haibo Jiang, Christer Betsholtz, Maarja Andaloussi Mäe, Liqun He, Anne P. Beigneux, Loren G. Fong, and Stephen G. Young GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs. The Journal of clinical investigation vol. 135,19 e191867. 1 Oct. 2025, doi:10.1172/JCI191867
Nguyen LP, Song W, Yang Y, Tran AP, Weston T, Jung H, Tu Y, Kim PH, Kim JR, Xie K, Yu RG, Scheihauer J, Presnell A, Ploug M, Birrane G, Goodwin JL, Arnold H, Koltowska K, Mäe MA, He L, Betsholtz C, Beigneux AP, Fong LG, Young SG. Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species. JCI Insight 9(20): e184940. PMC11529983
Yang Y, Konrad RJ, Ploug M, Young SG. APOA5 deficiency causes hypertriglyceridemia by reducing amounts of lipoprotein lipase in capillaries. (2024) J. Lipid Res. 65(7):100578. doi: 10.1016/j.jlr.2024.100578.. PMID: 38880127. PMC11299584.
Chen YQ, Yang Y, Zhen EY, Beyer TP, Li H, Wen Y, Ehsani M, Xie K, Jung H, Scheithauer JL, Jackson N, Kumari A, Birrane G, Russell AM, Balasubramaniam D, Liao Z, Siegel RW, Quian Y, Ploug M, Young SG, Konrad RJ. (2024) Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity. Proc Natl Acad Sci USA 121(17) e2322332121. PMID: 38625948 https://doi.org/10.1073/pnas.2322332121. PMC11046700. *