Publications
2023
Recent Publications
Nuclear Lamins
- Kim JR, Kim PH, Presnell A, Tu Y, Young SG. (2023). Revisiting the truncated lamin A produced by a commonly used strain of Lmna knockout mice. Nucleus.14(1):2262308. doi: 10.1080/19491034.2023.2262308.
Triglyceride Metabolism
- Song W, Beigneux AP, Weston TA, Chen K, Yang Y, Nguyen L-P, Guagliardo P, Jung H, Tran AP, Tu Y, Tran C, Birrane B, Miyashita K, Nakajima K, Murakami M, Tontonoz P, Jiang H, Ploug M, Fong LG, Young SG. (2023) The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing. J Clin Invest.120(40):e2313825120. doi: 10.1073/pnas.2313825120. PMC37871217.
- Yang Y, Beigneux AP, Song W, Nuuyen L-P, Jung H, Tu Y, Weston TA, Tran CM, Xie K, Yu RG, Tran AP, Miyashita K, Nakajima K, Murakami M, Chen YQ, Zhen EY, Kim J, Kim PH, Birrane G, Tontonoz P, Ploug M, Konrad RJ, Fong LG, and Young SG. (2023) Hypertriglyceridemia in Apoa5–/– mice results from reduced amounts of lipoprotein lipase in the capillary lumen. Proc Natl Acad Sci U S A.132(5):e172600. doi: 10.1172/JCI172600.
Pictured: Confocal microscope images. CHO-K1 cells with LPL, DAPI, and LPL+DAPI detection.
- Wenxin S, Yang Y, Heizer P, Tu Y, Weston TA, Kim J, Munguia P, Jung H, Fong, J, Tran, CM, Ploug M, Beigneux AP, Young SG, Fong LG. (2023). Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures. Proceedings of the National Academy of Sciences of the United States of America. 120. e2219833120. 10.1073/pnas.2219833120.
Pictured: Confocal microscope images. BAT (brown adipose tissue) at RT and 30°C. Columns: LPL, GPIHBP1, CD31, LPL+GPIHBP1, Merge+Nucleus.